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Target Snapshot

CHEMBL1075476 Target Snapshot

HuO9 · CELL-LINE · Homo sapiens

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73Compounds
1Assays
20Approved Drugs
74.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HuO9 as ChEMBL target CHEMBL1075476. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HuO9
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075476
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HuO9 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHuO9
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuO9
UniProt AccessionN/A

HuO9

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HuO9.

Review nameHuO9
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
6
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC5074.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 8.54 IC50 2.881 Preclinical
CHEMBL3545252 8.46 IC50 3.456 Approved
CHEMBL553025 8.15 IC50 7.092 Approved
CHEMBL159 7.9 IC50 12.64 Approved
CHEMBL1972860 7.67 IC50 21.54 Clinical
CHEMBL1879463 7.57 IC50 26.76 Clinical
CHEMBL1171837 7.26 IC50 54.48 Approved
CHEMBL109480 7.12 IC50 75.89 Clinical
CHEMBL1201182 6.75 IC50 177.44 Approved
CHEMBL521851 6.69 IC50 206.02 Clinical
Distribution

pChEMBL Value Distribution

10
5.0
8
5.5
7
6.0
4
6.5
2
7.0
3
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
73
Tested Compounds
1
Assay Types
Functional — 1 assays, 73 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 73 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine