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Target Snapshot

CHEMBL1075488 Target Snapshot

KYSE-450 · CELL-LINE · Homo sapiens

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321Compounds
50Assays
24Approved Drugs
320.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KYSE-450 as ChEMBL target CHEMBL1075488. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KYSE-450
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075488
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KYSE-450 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKYSE-450
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKYSE-450
UniProt AccessionN/A

KYSE-450

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KYSE-450.

Review nameKYSE-450
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
9
Phase III
9
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50320.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL94657 9.57 IC50 0.2674 Clinical
CHEMBL2107358 9.33 IC50 0.469 Clinical
CHEMBL96926 9.11 IC50 0.7766 Preclinical
CHEMBL3545252 8.84 IC50 1.432 Approved
CHEMBL3622533 8.7 IC50 2.0 Clinical
CHEMBL888 8.2 IC50 6.315 Approved
CHEMBL159 8.02 IC50 9.649 Approved
CHEMBL553025 8.01 IC50 9.741 Approved
CHEMBL67 7.92 IC50 12.0 Preclinical
CHEMBL252164 7.87 IC50 13.49 Clinical
Distribution

pChEMBL Value Distribution

23
5.0
18
5.5
36
6.0
38
6.5
29
7.0
6
7.5
3
8.0
2
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

50
Total Assays
236
Tested Compounds
1
Assay Types
Functional — 50 assays, 236 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 48 236 6.0
organism-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine