Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL1075497 Target Snapshot

MDA-MB-175-VII · CELL-LINE · Homo sapiens

104Compounds
11Assays
18Approved Drugs
101.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MDA-MB-175-VII as ChEMBL target CHEMBL1075497. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MDA-MB-175-VII
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075497
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MDA-MB-175-VII still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMDA-MB-175-VII
UniProt AccessionN/A

MDA-MB-175-VII

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MDA-MB-175-VII.

Review nameMDA-MB-175-VII
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

18
Approved
9
Phase III
9
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50101.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL109480 7.47 IC50 33.54 Clinical
CHEMBL1173655 7.47 IC50 34.16 Approved
CHEMBL1879463 7.4 IC50 39.51 Clinical
CHEMBL3545252 7.36 IC50 44.17 Approved
CHEMBL65 7.08 IC50 83.02 Preclinical
CHEMBL507361 6.96 IC50 109.26 Clinical
CHEMBL1079175 6.86 IC50 137.38 Clinical
CHEMBL159 6.57 IC50 267.63 Approved
CHEMBL449158 6.57 IC50 268.63 Clinical
CHEMBL553025 6.55 IC50 280.65 Approved
Distribution

pChEMBL Value Distribution

8
5.0
10
5.5
11
6.0
5
6.5
5
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

11
Total Assays
100
Tested Compounds
1
Assay Types
Functional — 11 assays, 100 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 100 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine