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Target Snapshot

CHEMBL1075503 Target Snapshot

MFE-296 · CELL-LINE · Homo sapiens

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105Compounds
34Assays
9Approved Drugs
42.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MFE-296 as ChEMBL target CHEMBL1075503. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MFE-296
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075503
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MFE-296 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMFE-296
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMFE-296
UniProt AccessionN/A

MFE-296

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MFE-296.

Review nameMFE-296
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

9
Approved
3
Phase III
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5042.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL94657 8.57 IC50 2.684 Clinical
CHEMBL96926 8.53 IC50 2.946 Preclinical
CHEMBL553025 8.22 IC50 5.989 Approved
CHEMBL252164 7.63 IC50 23.22 Clinical
CHEMBL888 7.29 IC50 51.35 Approved
CHEMBL53463 7.15 IC50 70.49 Approved
CHEMBL3659991 7.01 IC50 98.0 Preclinical
CHEMBL1171837 6.93 IC50 118.39 Approved
CHEMBL3659990 6.87 IC50 134.0 Preclinical
CHEMBL2107358 6.86 IC50 138.64 Clinical
Distribution

pChEMBL Value Distribution

1
5.0
7
5.5
4
6.0
6
6.5
3
7.0
1
7.5
1
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
PAZOPANIB
CHEMBL477772
Approved 2009
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

34
Total Assays
41
Tested Compounds
1
Assay Types
Functional — 34 assays, 41 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 30 41 6.1
organism-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine