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Target Snapshot

CHEMBL1075504 Target Snapshot

MFM-223 · CELL-LINE · Homo sapiens

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141Compounds
8Assays
19Approved Drugs
143.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MFM-223 as ChEMBL target CHEMBL1075504. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MFM-223
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075504
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MFM-223 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMFM-223
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMFM-223
UniProt AccessionN/A

MFM-223

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MFM-223.

Review nameMFM-223
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

19
Approved
9
Phase III
9
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50143.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 8.21 IC50 6.156 Approved
CHEMBL1738758 8.0 IC50 10.0 Clinical
CHEMBL325041 7.75 IC50 17.91 Clinical
CHEMBL1972860 7.34 IC50 45.2 Clinical
CHEMBL5178057 7.33 IC50 47.0 Preclinical
CHEMBL1879463 6.88 IC50 131.51 Clinical
CHEMBL159 6.87 IC50 135.5 Approved
CHEMBL189584 6.67 IC50 215.76 Preclinical
CHEMBL109480 6.58 IC50 263.63 Clinical
CHEMBL603469 6.48 IC50 333.11 Clinical
Distribution

pChEMBL Value Distribution

14
5.0
5
5.5
8
6.0
4
6.5
2
7.0
1
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AXITINIB
CHEMBL1289926
Approved 2012
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

8
Total Assays
140
Tested Compounds
1
Assay Types
Functional — 8 assays, 140 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 140 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine