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Target Snapshot

CHEMBL1075516 Target Snapshot

NCI-H1581 · CELL-LINE · Homo sapiens

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370Compounds
66Assays
29Approved Drugs
344.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H1581 as ChEMBL target CHEMBL1075516. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H1581
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075516
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H1581 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H1581
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H1581
UniProt AccessionN/A

NCI-H1581

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H1581.

Review nameNCI-H1581
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

29
Approved
11
Phase III
13
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50344.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.26 IC50 0.5498 Preclinical
CHEMBL3128043 9.22 IC50 0.6 Preclinical
CHEMBL4447359 9.15 IC50 0.7 Preclinical
CHEMBL4567187 9.15 IC50 0.7 Preclinical
CHEMBL3828439 9.1 IC50 0.8 Preclinical
CHEMBL3828740 9.0 IC50 1.0 Preclinical
CHEMBL3827492 8.96 IC50 1.1 Preclinical
CHEMBL3827725 8.92 IC50 1.2 Preclinical
CHEMBL4593639 8.89 IC50 1.3 Preclinical
CHEMBL4870179 8.89 IC50 1.3 Preclinical
Distribution

pChEMBL Value Distribution

29
5.0
29
5.5
24
6.0
23
6.5
25
7.0
22
7.5
15
8.0
15
8.5
6
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FUTIBATINIB
CHEMBL3701238
Approved 2022
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

66
Total Assays
265
Tested Compounds
1
Assay Types
Functional — 66 assays, 265 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 36 265 6.4
organism-based format 30 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine