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Target Snapshot

CHEMBL1075521 Target Snapshot

NCI-H1693 · CELL-LINE · Homo sapiens

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116Compounds
8Assays
24Approved Drugs
102.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H1693 as ChEMBL target CHEMBL1075521. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H1693
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075521
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H1693 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H1693
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H1693
UniProt AccessionN/A

NCI-H1693

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H1693.

Review nameNCI-H1693
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
11
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50101.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1972860 8.04 IC50 9.094 Clinical
CHEMBL65 7.57 IC50 26.69 Preclinical
CHEMBL252164 7.44 IC50 36.17 Clinical
CHEMBL3545252 7.37 IC50 43.05 Approved
CHEMBL888 7.34 IC50 46.09 Approved
CHEMBL159 7.11 IC50 78.21 Approved
CHEMBL1201182 7.04 IC50 92.17 Approved
CHEMBL449158 6.92 IC50 120.09 Clinical
CHEMBL1879463 6.87 IC50 136.12 Clinical
CHEMBL5400233 6.7 IC50 200.0 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
9
5.5
3
6.0
4
6.5
5
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

8
Total Assays
100
Tested Compounds
1
Assay Types
Functional — 8 assays, 100 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 100 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine