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Target Snapshot

CHEMBL1075527 Target Snapshot

NCI-H1993 · CELL-LINE · Homo sapiens

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323Compounds
41Assays
23Approved Drugs
330.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H1993 as ChEMBL target CHEMBL1075527. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H1993
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075527
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H1993 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H1993
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H1993
UniProt AccessionN/A

NCI-H1993

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H1993.

Review nameNCI-H1993
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

23
Approved
7
Phase III
11
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50329.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4064183 9.7 IC50 0.2 Preclinical
CHEMBL4076438 9.7 IC50 0.2 Preclinical
CHEMBL4104884 9.4 IC50 0.4 Preclinical
CHEMBL4091023 9.3 IC50 0.5 Preclinical
CHEMBL4074262 9.22 IC50 0.6 Preclinical
CHEMBL4070258 9.1 IC50 0.8 Preclinical
CHEMBL4097173 9.1 IC50 0.8 Preclinical
CHEMBL4060354 9.05 IC50 0.9 Preclinical
CHEMBL4061378 9.05 IC50 0.9 Preclinical
CHEMBL4070051 9.05 IC50 0.9 Preclinical
Distribution

pChEMBL Value Distribution

39
5.0
37
5.5
18
6.0
48
6.5
11
7.0
9
7.5
11
8.0
6
8.5
10
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

CAPMATINIB
CHEMBL3188267
Approved 2020
Properties Compare Identifier
CABOZANTINIB
CHEMBL2105717
Approved 2012
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

41
Total Assays
269
Tested Compounds
1
Assay Types
Functional — 41 assays, 269 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 34 269 6.2
organism-based format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine