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Target Snapshot

CHEMBL1075540 Target Snapshot

NCI-H2452 · CELL-LINE · Homo sapiens

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118Compounds
8Assays
20Approved Drugs
106.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H2452 as ChEMBL target CHEMBL1075540. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H2452
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075540
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H2452 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H2452
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H2452
UniProt AccessionN/A

NCI-H2452

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H2452.

Review nameNCI-H2452
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
6
Phase III
9
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50106.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 8.66 IC50 2.163 Approved
CHEMBL159 8.02 IC50 9.587 Approved
CHEMBL1972860 7.66 IC50 21.72 Clinical
CHEMBL1879463 7.35 IC50 44.58 Clinical
CHEMBL65 7.04 IC50 90.89 Preclinical
CHEMBL449158 6.88 IC50 133.45 Clinical
CHEMBL109480 6.86 IC50 139.56 Clinical
CHEMBL1201182 6.56 IC50 277.12 Approved
CHEMBL94657 6.55 IC50 278.65 Clinical
CHEMBL1801204 6.21 IC50 619.17 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
9
5.5
4
6.0
4
6.5
2
7.0
1
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

8
Total Assays
103
Tested Compounds
1
Assay Types
Functional — 8 assays, 103 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 103 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine