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Target Snapshot

CHEMBL1075557 Target Snapshot

PANC-03-27 · CELL-LINE · Homo sapiens

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103Compounds
5Assays
20Approved Drugs
101.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PANC-03-27 as ChEMBL target CHEMBL1075557. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PANC-03-27
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075557
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PANC-03-27 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePANC-03-27
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPANC-03-27
UniProt AccessionN/A

PANC-03-27

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PANC-03-27.

Review namePANC-03-27
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
9
Phase III
10
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50101.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 10.04 IC50 0.09108 Preclinical
CHEMBL94657 9.88 IC50 0.132 Clinical
CHEMBL4764390 9.0 IC50 1.0 Preclinical
CHEMBL3545252 8.81 IC50 1.537 Approved
CHEMBL888 8.45 IC50 3.513 Approved
CHEMBL159 8.26 IC50 5.472 Approved
CHEMBL553025 8.23 IC50 5.948 Approved
CHEMBL65 8.15 IC50 7.103 Preclinical
CHEMBL252164 7.93 IC50 11.62 Clinical
CHEMBL53463 7.55 IC50 28.16 Approved
Distribution

pChEMBL Value Distribution

16
5.0
9
5.5
5
6.0
8
6.5
3
7.0
3
7.5
4
8.0
1
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
100
Tested Compounds
1
Assay Types
Functional — 5 assays, 100 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 100 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine