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Target Snapshot

CHEMBL1075578 Target Snapshot

SK-N-AS · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
183Compounds
78Assays
27Approved Drugs
158.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SK-N-AS as ChEMBL target CHEMBL1075578. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SK-N-AS
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075578
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SK-N-AS still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSK-N-AS
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSK-N-AS
UniProt AccessionN/A

SK-N-AS

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SK-N-AS.

Review nameSK-N-AS
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

27
Approved
10
Phase III
10
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50150.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 8.27 IC50 5.377 Preclinical
CHEMBL3545252 8.27 IC50 5.352 Approved
CHEMBL507361 8.07 IC50 8.438 Clinical
CHEMBL159 8.06 IC50 8.669 Approved
CHEMBL1972860 7.52 IC50 30.04 Clinical
CHEMBL449158 7.37 IC50 43.13 Clinical
CHEMBL3349342 7.36 IC50 43.29 Preclinical
CHEMBL96926 7.31 IC50 48.51 Preclinical
CHEMBL3108948 7.09 IC50 81.0 Preclinical
CHEMBL1614701 7.03 IC50 92.83 Approved
Distribution

pChEMBL Value Distribution

14
5.0
24
5.5
17
6.0
7
6.5
5
7.0
1
7.5
4
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

78
Total Assays
134
Tested Compounds
2
Assay Types
Functional — 77 assays, 134 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 70 134 5.6
organism-based format 7 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine