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Target Snapshot

CHEMBL1075595 Target Snapshot

SW780 · CELL-LINE · Homo sapiens

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174Compounds
31Assays
22Approved Drugs
127.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW780 as ChEMBL target CHEMBL1075595. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW780
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075595
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW780 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW780
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW780
UniProt AccessionN/A

SW780

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW780.

Review nameSW780
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

22
Approved
8
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50127.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4100258 9.52 IC50 0.3 Preclinical
CHEMBL3545252 9.23 IC50 0.5865 Approved
CHEMBL428647 8.96 IC50 1.1 Approved
CHEMBL159 8.63 IC50 2.329 Approved
CHEMBL4060079 8.48 IC50 3.34 Preclinical
CHEMBL1201182 8.32 IC50 4.827 Approved
CHEMBL4092354 8.28 IC50 5.2 Preclinical
CHEMBL4068733 8.27 IC50 5.4 Preclinical
CHEMBL107 8.17 IC50 6.7 Approved
CHEMBL4079538 8.05 IC50 9.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
10
5.5
15
6.0
3
6.5
3
7.0
12
7.5
7
8.0
2
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

INFIGRATINIB PHOSPHATE
CHEMBL1834657
Approved 2021
Properties Compare Identifier
SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

31
Total Assays
123
Tested Compounds
1
Assay Types
Functional — 31 assays, 123 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 123 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine