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Target Snapshot

CHEMBL1075598 Target Snapshot

SW948 · CELL-LINE · Homo sapiens

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144Compounds
23Assays
20Approved Drugs
128.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW948 as ChEMBL target CHEMBL1075598. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW948
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075598
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW948 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW948
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW948
UniProt AccessionN/A

SW948

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW948.

Review nameSW948
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
7
Phase III
7
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50128.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3128043 8.37 IC50 4.3 Preclinical
CHEMBL94657 7.75 IC50 17.77 Clinical
CHEMBL553025 7.7 IC50 19.85 Approved
CHEMBL3545252 7.22 IC50 59.96 Approved
CHEMBL588564 7.16 IC50 70.0 Preclinical
CHEMBL159 7.12 IC50 75.99 Approved
CHEMBL1448 6.96 IC50 110.0 Approved
CHEMBL449158 6.91 IC50 122.56 Clinical
CHEMBL1738758 6.91 IC50 124.0 Clinical
CHEMBL65 6.8 IC50 160.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
6
5.5
3
6.0
5
6.5
3
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
NICLOSAMIDE
CHEMBL1448
Approved 1982
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

23
Total Assays
111
Tested Compounds
1
Assay Types
Functional — 23 assays, 111 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 111 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine