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Target Snapshot

CHEMBL1075604 Target Snapshot

UACC-812 · CELL-LINE · Homo sapiens

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74Compounds
8Assays
10Approved Drugs
71.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UACC-812 as ChEMBL target CHEMBL1075604. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UACC-812
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075604
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether UACC-812 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameUACC-812
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUACC-812
UniProt AccessionN/A

UACC-812

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as UACC-812.

Review nameUACC-812
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

10
Approved
4
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC5071.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 7.45 IC50 35.44 Clinical
CHEMBL449158 6.75 IC50 176.11 Clinical
CHEMBL562903 6.58 IC50 260.0 Preclinical
CHEMBL3414623 6.52 IC50 300.0 Preclinical
CHEMBL252164 6.33 IC50 467.76 Clinical
CHEMBL428647 6.16 IC50 700.0 Approved
CHEMBL525978 6.12 IC50 760.0 Preclinical
CHEMBL559349 6.09 IC50 810.0 Preclinical
CHEMBL94657 6.0 IC50 1003.75 Clinical
CHEMBL512504 5.94 IC50 1148.8 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
5
5.5
5
6.0
3
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

8
Total Assays
66
Tested Compounds
1
Assay Types
Functional — 8 assays, 66 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 66 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine