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Target Snapshot

CHEMBL1075605 Target Snapshot

UACC-893 · CELL-LINE · Homo sapiens

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95Compounds
5Assays
18Approved Drugs
96.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UACC-893 as ChEMBL target CHEMBL1075605. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UACC-893
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1075605
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether UACC-893 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameUACC-893
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUACC-893
UniProt AccessionN/A

UACC-893

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as UACC-893.

Review nameUACC-893
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

18
Approved
7
Phase III
7
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5096.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL94657 7.34 IC50 45.5 Clinical
CHEMBL3545252 7.26 IC50 54.62 Approved
CHEMBL252164 7.23 IC50 58.96 Clinical
CHEMBL96926 7.23 IC50 58.75 Preclinical
CHEMBL159 7.01 IC50 98.3 Approved
CHEMBL1173655 6.92 IC50 118.85 Approved
CHEMBL1760169 6.85 IC50 140.0 Preclinical
CHEMBL3414623 6.52 IC50 300.0 Preclinical
CHEMBL449158 6.42 IC50 378.95 Clinical
CHEMBL65 6.42 IC50 383.65 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
7
5.5
8
6.0
3
6.5
5
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
94
Tested Compounds
1
Assay Types
Functional — 5 assays, 94 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 94 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine