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Target Snapshot

CHEMBL1075613 Target Snapshot

ZR-75-30 · CELL-LINE · Homo sapiens

200Compounds
20Assays
13Approved Drugs
184.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ZR-75-30 as ChEMBL target CHEMBL1075613. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ZR-75-30
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1075613
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ZR-75-30 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelZR-75-30
UniProt AccessionN/A

ZR-75-30

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ZR-75-30.

Review nameZR-75-30
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
4
Phase III
6
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50182.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2153135 8.0 IC50 10.0 Preclinical
CHEMBL1972860 7.32 IC50 47.88 Clinical
CHEMBL1173655 7.02 IC50 95.45 Approved
CHEMBL2089142 6.91 IC50 122.0 Preclinical
CHEMBL3545252 6.68 IC50 206.43 Approved
CHEMBL65 6.62 IC50 240.0 Preclinical
CHEMBL1201182 6.55 IC50 282.83 Approved
CHEMBL159 6.39 IC50 402.55 Approved
CHEMBL4093702 6.38 IC50 420.0 Preclinical
CHEMBL1231795 5.92 EC50 1200.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
14
5.5
2
6.0
5
6.5
2
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
DOCETAXEL
CHEMBL3545252
Approved 1995
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

20
Total Assays
106
Tested Compounds
2
Assay Types
Functional — 19 assays, 106 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 106 5.1
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine