STE20/SPS1-related proline-alanine-rich protein kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UEW8. Use UniProt Q9UEW8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UEW8 as the stable identity anchor, then attach disease evidence before program review.
STE20/SPS1-related proline-alanine-rich protein kinase
Review this target as STE20/SPS1-related proline-alanine-rich protein kinase, mapped to UniProt Q9UEW8. Sequence length is 545 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats STE20/SPS1-related proline-alanine-rich protein kinase as ChEMBL target CHEMBL1163108, mapped to UniProt Q9UEW8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | STE20/SPS1-related proline-alanine-rich protein kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UEW8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | STE20/SPS1-related proline-alanine-rich protein kinase |
| UniProt Accession | Q9UEW8 |
| Component Type | Protein |
| Sequence Length | 545 aa |
STE20/SPS1-related proline-alanine-rich protein kinase
Review this target as STE20/SPS1-related proline-alanine-rich protein kinase, mapped to UniProt Q9UEW8. Sequence length is 545 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 7.84 | IC50 | 14.4 | Preclinical |
| CHEMBL5433617 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL4792789 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL4762099 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL388978 | 6.89 | Kd | 130.0 | Preclinical |
| CHEMBL535 | 6.85 | Kd | 140.0 | Approved |
| CHEMBL509032 | 6.82 | Kd | 150.0 | Preclinical |
| CHEMBL4759888 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL4797256 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL1721885 | 6.37 | Kd | 430.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 99 | 43 | 6.1 |
| assay format | 16 | 1 | 5.0 |
| subcellular format | 10 | 0 | — |
| cell-based format | 9 | 0 | — |