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Target Snapshot

CHEMBL1163116 Target Snapshot

Cholesteryl ester transfer protein · SINGLE PROTEIN · Oryctolagus cuniculus

219Compounds
7Assays
0Approved Drugs
133.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P22687. Use UniProt P22687 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P22687 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cholesteryl ester transfer protein as ChEMBL target CHEMBL1163116, mapped to UniProt P22687. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cholesteryl ester transfer protein
SINGLE PROTEIN · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL1163116
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P22687
Cholesteryl ester transfer protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cholesteryl ester transfer protein is the right protein anchor across sources, using UniProt P22687 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCholesteryl ester transfer protein
UniProt AccessionP22687
Component TypeProtein
Sequence Length497 aa

Cholesteryl ester transfer protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cholesteryl ester transfer protein, mapped to UniProt P22687. Sequence length is 497 aa.

Mapped IDP22687
Review nameCholesteryl ester transfer protein
OrganismOryctolagus cuniculus
Assay Mix

Activity Type Distribution

IC50133.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL127130 8.92 IC50 1.2 Preclinical
CHEMBL446661 8.52 IC50 3.0 Preclinical
CHEMBL67129 8.4 IC50 4.0 Preclinical
CHEMBL67117 8.09 IC50 8.1 Preclinical
CHEMBL304170 7.92 IC50 12.0 Preclinical
CHEMBL303954 7.7 IC50 20.0 Preclinical
CHEMBL69699 7.7 IC50 20.0 Preclinical
CHEMBL302797 7.52 IC50 30.0 Preclinical
CHEMBL308436 7.52 IC50 30.0 Preclinical
CHEMBL69563 7.52 IC50 30.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
10
5.5
20
6.0
15
6.5
19
7.0
7
7.5
2
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
122
Tested Compounds
1
Assay Types
Binding — 7 assays, 122 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 122 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine