Cyclin-dependent kinase-like 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8IVW4. Use UniProt Q8IVW4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8IVW4 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase-like 3
Review this target as Cyclin-dependent kinase-like 3, mapped to UniProt Q8IVW4. Sequence length is 592 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase-like 3 as ChEMBL target CHEMBL1163117, mapped to UniProt Q8IVW4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-dependent kinase-like 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8IVW4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase-like 3 |
| UniProt Accession | Q8IVW4 |
| Component Type | Protein |
| Sequence Length | 592 aa |
Cyclin-dependent kinase-like 3
Review this target as Cyclin-dependent kinase-like 3, mapped to UniProt Q8IVW4. Sequence length is 592 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5426285 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL574738 | 8.41 | Kd | 3.9 | Preclinical |
| CHEMBL574738 | 8.15 | IC50 | 7.1 | Preclinical |
| CHEMBL5190023 | 6.84 | IC50 | 143.0 | Preclinical |
| CHEMBL572878 | 6.46 | Kd | 350.0 | Clinical |
| CHEMBL603469 | 6.37 | Kd | 430.0 | Clinical |
| CHEMBL1336 | 6.31 | Kd | 490.0 | Approved |
| CHEMBL5393904 | 6.17 | IC50 | 668.5 | Preclinical |
| CHEMBL379218 | 5.96 | Kd | 1100.0 | Preclinical |
| CHEMBL388978 | 5.96 | IC50 | 1100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 73 | 12 | 6.5 |
| assay format | 17 | 0 | — |
| cell-based format | 2 | 0 | — |