Mitogen-activated protein kinase kinase kinase 6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O95382. Use UniProt O95382 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O95382 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase 6
Review this target as Mitogen-activated protein kinase kinase kinase 6, mapped to UniProt O95382. Sequence length is 1288 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 6 as ChEMBL target CHEMBL1163123, mapped to UniProt O95382. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O95382 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 6 |
| UniProt Accession | O95382 |
| Component Type | Protein |
| Sequence Length | 1288 aa |
Mitogen-activated protein kinase kinase kinase 6
Review this target as Mitogen-activated protein kinase kinase kinase 6, mapped to UniProt O95382. Sequence length is 1288 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5746514 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL5937217 | 8.08 | IC50 | 8.32 | Preclinical |
| CHEMBL6036447 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL5812512 | 7.8 | IC50 | 15.8 | Preclinical |
| CHEMBL388978 | 7.04 | IC50 | 90.8 | Preclinical |
| CHEMBL603469 | 6.77 | Kd | 170.0 | Clinical |
| CHEMBL4763562 | 6.7 | IC50 | 200.8 | Preclinical |
| CHEMBL388978 | 6.58 | Kd | 260.0 | Preclinical |
| CHEMBL4764071 | 6.58 | IC50 | 264.4 | Preclinical |
| CHEMBL281948 | 6.47 | Kd | 335.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 64 | 28 | 6.3 |
| assay format | 14 | 0 | — |
| cell-based format | 13 | 0 | — |
| subcellular format | 12 | 7 | 6.1 |