Bifunctional dihydrofolate reductase-thymidylate synthase · SINGLE PROTEIN · Trypanosoma cruzi
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As of 2026-09-14Protein identity stays anchored to UniProt Q27793. Use UniProt Q27793 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q27793 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q27793. Sequence length is 521 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional dihydrofolate reductase-thymidylate synthase as ChEMBL target CHEMBL1163130, mapped to UniProt Q27793. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Bifunctional dihydrofolate reductase-thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
| UniProt | Q27793 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional dihydrofolate reductase-thymidylate synthase |
| UniProt Accession | Q27793 |
| Component Type | Protein |
| Sequence Length | 521 aa |
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q27793. Sequence length is 521 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL34259 | 8.96 | IC50 | 1.1 | Approved |
| CHEMBL1165388 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL1163286 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL1165305 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL1165306 | 8.48 | Ki | 3.3 | Preclinical |
| CHEMBL1164279 | 8.44 | Ki | 3.6 | Preclinical |
| CHEMBL5914970 | 8.25 | IC50 | 5.62 | Preclinical |
| CHEMBL5941843 | 8.25 | IC50 | 5.62 | Preclinical |
| CHEMBL5838395 | 8.21 | IC50 | 6.17 | Preclinical |
| CHEMBL119 | 8.18 | Ki | 6.6 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 21 | 7.8 |