Serine/threonine-protein kinase A-Raf · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Serine/threonine-protein kinase A-Raf shows clinical signal disease relevance led by colorectal neoplasm. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P10398. Start with colorectal neoplasm, then reuse UniProt P10398 as the stable protein anchor across project notes and exports.
Start with colorectal neoplasm, then reuse UniProt P10398 as the stable protein anchor across project notes and exports.
Serine/threonine-protein kinase A-Raf shows clinical signal disease relevance led by colorectal neoplasm. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with colorectal neoplasm because it currently carries clinical signal support. Linked drugs include LY-3009120. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySerine/threonine-protein kinase A-Raf
Review this target as Serine/threonine-protein kinase A-Raf, mapped to UniProt P10398. Sequence length is 606 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase A-Raf as ChEMBL target CHEMBL1169596, mapped to UniProt P10398. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Serine/threonine-protein kinase A-Raf is the right protein anchor across sources, using UniProt P10398 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why colorectal neoplasm is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Serine/threonine-protein kinase A-Raf |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10398 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase A-Raf |
| UniProt Accession | P10398 |
| Component Type | Protein |
| Sequence Length | 606 aa |
Serine/threonine-protein kinase A-Raf
Review this target as Serine/threonine-protein kinase A-Raf, mapped to UniProt P10398. Sequence length is 606 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Serine/threonine-protein kinase A-Raf shows clinical signal disease relevance led by colorectal neoplasm. 3 more disease programs remain visible in the same review block.
Start review with colorectal neoplasm because it currently carries clinical signal support. Linked drugs include LY-3009120. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4466555 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3577124 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL1229517 | 8.68 | IC50 | 2.1 | Approved |
| CHEMBL5095099 | 8.62 | IC50 | 2.4 | Clinical |
| CHEMBL4207519 | 8.25 | IC50 | 5.6 | Preclinical |
| CHEMBL1336 | 8.15 | IC50 | 7.1 | Approved |
| CHEMBL4438236 | 8.07 | IC50 | 8.6 | Preclinical |
| CHEMBL1880739 | 7.84 | IC50 | 14.6 | Preclinical |
| CHEMBL4060057 | 7.75 | IC50 | 17.8 | Preclinical |
| CHEMBL4075036 | 7.6 | IC50 | 25.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 72 | 30 | 7.4 |
| cell-based format | 12 | 6 | 6.9 |
| subcellular format | 6 | 4 | 5.8 |