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Target Snapshot

CHEMBL1169599 Target Snapshot

KiSS-1 receptor · SINGLE PROTEIN · Rattus norvegicus

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105Compounds
7Assays
0Approved Drugs
142.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q924U1. Use UniProt Q924U1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q924U1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KiSS-1 receptor as ChEMBL target CHEMBL1169599, mapped to UniProt Q924U1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KiSS-1 receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL1169599
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q924U1
KiSS-1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KiSS-1 receptor is the right protein anchor across sources, using UniProt Q924U1 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKiSS-1 receptor
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtQ924U1
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKiSS-1 receptor
UniProt AccessionQ924U1
Component TypeProtein
Sequence Length396 aa

KiSS-1 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KiSS-1 receptor, mapped to UniProt Q924U1. Sequence length is 396 aa.

Mapped IDQ924U1
Review nameKiSS-1 receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

3
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5023.0
KI55.0
EC5064.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3087793 10.4 Ki 0.04 Preclinical
CHEMBL3087925 10.38 Ki 0.042 Preclinical
CHEMBL3087927 10.37 Ki 0.043 Preclinical
CHEMBL3086282 10.29 Ki 0.051 Preclinical
CHEMBL376756 10.24 Ki 0.057 Clinical
CHEMBL3085809 10.23 Ki 0.059 Preclinical
CHEMBL2151646 10.17 Ki 0.068 Preclinical
CHEMBL3314224 10.16 Ki 0.069 Preclinical
CHEMBL3085804 10.15 Ki 0.07 Preclinical
CHEMBL3087929 10.12 Ki 0.076 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
3
6.5
10
7.0
21
7.5
27
8.0
14
8.5
6
9.0
28
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
60
Tested Compounds
2
Assay Types
Binding — 5 assays, 58 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 39 9.7
cell-based format 2 19 8.8
Functional — 2 assays, 60 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 60 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine