5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase · SINGLE PROTEIN · Escherichia coli O157:H7
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As of 2026-09-14Protein identity stays anchored to UniProt P0AF14. Use UniProt P0AF14 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0AF14 as the stable identity anchor, then attach disease evidence before program review.
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Review this target as 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, mapped to UniProt P0AF14. Sequence length is 232 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase as ChEMBL target CHEMBL1250346, mapped to UniProt P0AF14. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli O157:H7 |
| UniProt | P0AF14 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| UniProt Accession | P0AF14 |
| Component Type | Protein |
| Sequence Length | 232 aa |
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Review this target as 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, mapped to UniProt P0AF14. Sequence length is 232 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL405346 | 10.32 | Ki | 0.048 | Preclinical |
| CHEMBL405371 | 9.35 | Ki | 0.45 | Preclinical |
| CHEMBL407216 | 9.08 | Ki | 0.84 | Preclinical |
| CHEMBL154234 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL207655 | 8.77 | Ki | 1.7 | Preclinical |
| CHEMBL349317 | 8.47 | Ki | 3.4 | Preclinical |
| CHEMBL154218 | 8.41 | Ki | 3.9 | Preclinical |
| CHEMBL3604360 | 8.35 | Ki | 4.5 | Preclinical |
| CHEMBL345254 | 8.09 | Ki | 8.1 | Preclinical |
| CHEMBL156794 | 7.97 | Ki | 10.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 45 | 6.8 |
| assay format | 3 | 2 | 9.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |