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Target Snapshot

CHEMBL1250368 Target Snapshot

Enoyl-acyl carrier reductase · SINGLE PROTEIN · Toxoplasma gondii

51Compounds
6Assays
1Approved Drugs
40.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q6UCJ9. Use UniProt Q6UCJ9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q6UCJ9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Enoyl-acyl carrier reductase as ChEMBL target CHEMBL1250368, mapped to UniProt Q6UCJ9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Enoyl-acyl carrier reductase
SINGLE PROTEIN · Toxoplasma gondii
As of 2026-09-13
ChEMBL target ID
CHEMBL1250368
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q6UCJ9
Enoyl-acyl carrier reductase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Enoyl-acyl carrier reductase is the right protein anchor across sources, using UniProt Q6UCJ9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEnoyl-acyl carrier reductase
UniProt AccessionQ6UCJ9
Component TypeProtein
Sequence Length417 aa

Enoyl-acyl carrier reductase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Enoyl-acyl carrier reductase, mapped to UniProt Q6UCJ9. Sequence length is 417 aa.

Mapped IDQ6UCJ9
Review nameEnoyl-acyl carrier reductase
OrganismToxoplasma gondii
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5040.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL849 7.82 IC50 15.0 Approved
CHEMBL2392450 7.72 IC50 19.0 Preclinical
CHEMBL2392447 7.54 IC50 29.0 Preclinical
CHEMBL2347846 7.52 IC50 30.0 Preclinical
CHEMBL2392448 7.47 IC50 34.0 Preclinical
CHEMBL2347845 7.39 IC50 41.0 Preclinical
CHEMBL2347835 7.24 IC50 58.0 Preclinical
CHEMBL1240784 6.89 IC50 130.0 Preclinical
CHEMBL2347828 6.87 IC50 135.0 Preclinical
CHEMBL2392449 6.86 IC50 137.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
3
5.5
2
6.0
7
6.5
3
7.0
5
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TRICLOSAN
CHEMBL849
Approved 1997
Assay Landscape

Assay Landscape

6
Total Assays
19
Tested Compounds
1
Assay Types
Binding — 6 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 19 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine