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Target Snapshot

CHEMBL1250404 Target Snapshot

Cytochrome c oxidase subunit 2 · SINGLE PROTEIN · Ovis aries

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14Compounds
5Assays
1Approved Drugs
17.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O78750. Use UniProt O78750 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O78750 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome c oxidase subunit 2 as ChEMBL target CHEMBL1250404, mapped to UniProt O78750. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome c oxidase subunit 2
SINGLE PROTEIN · Ovis aries
As of 2026-09-14
ChEMBL target ID
CHEMBL1250404
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O78750
Cytochrome c oxidase subunit 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome c oxidase subunit 2 is the right protein anchor across sources, using UniProt O78750 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCytochrome c oxidase subunit 2
Target TypeSINGLE PROTEIN
OrganismOvis aries
UniProtO78750
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome c oxidase subunit 2
UniProt AccessionO78750
Component TypeProtein
Sequence Length227 aa

Cytochrome c oxidase subunit 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cytochrome c oxidase subunit 2, mapped to UniProt O78750. Sequence length is 227 aa.

Mapped IDO78750
Review nameCytochrome c oxidase subunit 2
OrganismOvis aries
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5017.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5193790 8.19 IC50 6.4 Preclinical
CHEMBL5174073 8.15 IC50 7.15 Preclinical
CHEMBL118 7.37 IC50 42.6 Approved
CHEMBL1254872 7.24 IC50 57.0 Preclinical
CHEMBL1254784 7.16 IC50 69.0 Preclinical
CHEMBL1254785 7.11 IC50 77.0 Preclinical
CHEMBL1254873 7.11 IC50 77.0 Preclinical
CHEMBL1254699 7.1 IC50 80.0 Preclinical
CHEMBL1254700 7.07 IC50 85.0 Preclinical
CHEMBL579203 7.04 IC50 91.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
1
6.0
3
6.5
10
7.0
0
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 5 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 14 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine