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Target Snapshot

CHEMBL1250411 Target Snapshot

Short transient receptor potential channel 5 · SINGLE PROTEIN · Homo sapiens

264Compounds
61Assays
0Approved Drugs
293.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9UL62. Use UniProt Q9UL62 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UL62 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Short transient receptor potential channel 5 as ChEMBL target CHEMBL1250411, mapped to UniProt Q9UL62. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Short transient receptor potential channel 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1250411
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9UL62
Short transient receptor potential channel 5
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Short transient receptor potential channel 5 is the right protein anchor across sources, using UniProt Q9UL62 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelShort transient receptor potential channel 5
UniProt AccessionQ9UL62
Component TypeProtein
Sequence Length973 aa

Short transient receptor potential channel 5

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Short transient receptor potential channel 5, mapped to UniProt Q9UL62. Sequence length is 973 aa.

Mapped IDQ9UL62
Review nameShort transient receptor potential channel 5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50289.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4546097 9.28 IC50 0.52 Preclinical
CHEMBL4466522 8.89 IC50 1.3 Clinical
CHEMBL3945449 8.73 IC50 1.84 Preclinical
CHEMBL3920228 8.72 IC50 1.91 Preclinical
CHEMBL5598527 8.7 IC50 2.0 Preclinical
CHEMBL4466158 8.58 IC50 2.64 Preclinical
CHEMBL4525688 8.57 IC50 2.69 Preclinical
CHEMBL5597024 8.3 IC50 5.0 Preclinical
CHEMBL4451083 8.28 IC50 5.3 Preclinical
CHEMBL2024567 8.12 EC50 7.59 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
30
5.5
36
6.0
28
6.5
11
7.0
11
7.5
11
8.0
6
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

61
Total Assays
148
Tested Compounds
2
Assay Types
Binding — 60 assays, 148 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 50 143 6.4
single protein format 6 5 5.5
assay format 4 0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine