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Target Snapshot

CHEMBL1255145 Target Snapshot

Class D beta-lactamase · SINGLE PROTEIN · Brachyspira pilosicoli

10Compounds
4Assays
3Approved Drugs
3.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q50H31. Use UniProt Q50H31 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q50H31 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Class D beta-lactamase as ChEMBL target CHEMBL1255145, mapped to UniProt Q50H31. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Class D beta-lactamase
SINGLE PROTEIN · Brachyspira pilosicoli
As of 2026-09-13
ChEMBL target ID
CHEMBL1255145
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q50H31
beta-lactamase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Class D beta-lactamase is the right protein anchor across sources, using UniProt Q50H31 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelbeta-lactamase
UniProt AccessionQ50H31
Component TypeProtein
Sequence Length268 aa

beta-lactamase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Class D beta-lactamase, mapped to UniProt Q50H31. ChEMBL maps the protein component as beta-lactamase. Sequence length is 268 aa.

Mapped IDQ50H31
Review nameClass D beta-lactamase
OrganismBrachyspira pilosicoli
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL404 6.8 IC50 160.0 Approved
CHEMBL777 5.7 IC50 2000.0 Approved
CHEMBL403 4.92 IC50 12000.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZOBACTAM
CHEMBL404
Approved 1993
Assay Landscape

Assay Landscape

4
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 3 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine