Protein-serine O-palmitoleoyltransferase porcupine · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein-serine O-palmitoleoyltransferase porcupine shows clinical signal disease relevance led by squamous cell carcinoma. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9H237. Start with squamous cell carcinoma, then reuse UniProt Q9H237 as the stable protein anchor across project notes and exports.
Start with squamous cell carcinoma, then reuse UniProt Q9H237 as the stable protein anchor across project notes and exports.
Protein-serine O-palmitoleoyltransferase porcupine shows clinical signal disease relevance led by squamous cell carcinoma. 1 linked drug remains visible in the same block.
Start review with squamous cell carcinoma because it currently carries clinical signal support. Linked drugs include WNT-974. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProtein-serine O-palmitoleoyltransferase porcupine
Review this target as Protein-serine O-palmitoleoyltransferase porcupine, mapped to UniProt Q9H237. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein-serine O-palmitoleoyltransferase porcupine as ChEMBL target CHEMBL1255163, mapped to UniProt Q9H237. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Protein-serine O-palmitoleoyltransferase porcupine is the right protein anchor across sources, using UniProt Q9H237 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why squamous cell carcinoma is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Protein-serine O-palmitoleoyltransferase porcupine |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9H237 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein-serine O-palmitoleoyltransferase porcupine |
| UniProt Accession | Q9H237 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Protein-serine O-palmitoleoyltransferase porcupine
Review this target as Protein-serine O-palmitoleoyltransferase porcupine, mapped to UniProt Q9H237. Sequence length is 461 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Protein-serine O-palmitoleoyltransferase porcupine shows clinical signal disease relevance led by squamous cell carcinoma.
Start review with squamous cell carcinoma because it currently carries clinical signal support. Linked drugs include WNT-974. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2139947 | 10.13 | IC50 | 0.074 | Preclinical |
| CHEMBL3623895 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL3623894 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL3623875 | 9.64 | IC50 | 0.23 | Preclinical |
| CHEMBL3623896 | 9.42 | IC50 | 0.38 | Preclinical |
| CHEMBL3188386 | 9.4 | IC50 | 0.4 | Clinical |
| CHEMBL4080208 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3633801 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL3623893 | 9.28 | IC50 | 0.53 | Preclinical |
| CHEMBL3623892 | 9.17 | IC50 | 0.67 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 25 | 60 | 8.0 |
| single protein format | 4 | 5 | 8.5 |
| assay format | 2 | 0 | — |