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Target Snapshot

CHEMBL1275210 Target Snapshot

Stearoyl-CoA desaturase 5 · SINGLE PROTEIN · Homo sapiens

484Compounds
6Assays
0Approved Drugs
484.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q86SK9. Use UniProt Q86SK9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q86SK9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Stearoyl-CoA desaturase 5 as ChEMBL target CHEMBL1275210, mapped to UniProt Q86SK9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Stearoyl-CoA desaturase 5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1275210
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q86SK9
Stearoyl-CoA desaturase 5
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Stearoyl-CoA desaturase 5 is the right protein anchor across sources, using UniProt Q86SK9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelStearoyl-CoA desaturase 5
UniProt AccessionQ86SK9
Component TypeProtein
Sequence Length330 aa

Stearoyl-CoA desaturase 5

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Stearoyl-CoA desaturase 5, mapped to UniProt Q86SK9. Sequence length is 330 aa.

Mapped IDQ86SK9
Review nameStearoyl-CoA desaturase 5
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50483.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5653589 8.89 Kd 1.275 Preclinical
CHEMBL1950397 8.4 IC50 4.0 Preclinical
CHEMBL5842076 8.0 IC50 10.0 Preclinical
CHEMBL6023405 7.7 IC50 20.0 Preclinical
CHEMBL5798346 7.52 IC50 30.0 Preclinical
CHEMBL5902146 7.52 IC50 30.0 Preclinical
CHEMBL5911338 7.52 IC50 30.0 Preclinical
CHEMBL1950546 7.5 IC50 32.0 Preclinical
CHEMBL5839703 7.4 IC50 40.0 Preclinical
CHEMBL5857575 7.33 IC50 47.0 Preclinical
Distribution

pChEMBL Value Distribution

50
5.0
39
5.5
28
6.0
7
6.5
13
7.0
5
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

6
Total Assays
240
Tested Compounds
1
Assay Types
Binding — 6 assays, 240 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 240 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine