Glucosylceramidase · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt Q2KHZ8. Use UniProt Q2KHZ8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q2KHZ8 as the stable identity anchor, then attach disease evidence before program review.
Lysosomal acid glucosylceramidase
Review this target as Glucosylceramidase, mapped to UniProt Q2KHZ8. ChEMBL maps the protein component as Lysosomal acid glucosylceramidase. Sequence length is 536 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glucosylceramidase as ChEMBL target CHEMBL1275219, mapped to UniProt Q2KHZ8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glucosylceramidase |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | Q2KHZ8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysosomal acid glucosylceramidase |
| UniProt Accession | Q2KHZ8 |
| Component Type | Protein |
| Sequence Length | 536 aa |
Lysosomal acid glucosylceramidase
Review this target as Glucosylceramidase, mapped to UniProt Q2KHZ8. ChEMBL maps the protein component as Lysosomal acid glucosylceramidase. Sequence length is 536 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5592849 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5589663 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5589982 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5593532 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5591684 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5595884 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5591053 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5590768 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5595646 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL5592633 | 7.43 | IC50 | 37.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 16 | 63 | 5.9 |