Heat shock cognate 71 kDa protein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Heat shock cognate 71 kDa protein shows late clinical disease relevance led by systemic lupus erythematosus. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P11142. Start with systemic lupus erythematosus, then reuse UniProt P11142 as the stable protein anchor across project notes and exports.
Start with systemic lupus erythematosus, then reuse UniProt P11142 as the stable protein anchor across project notes and exports.
Heat shock cognate 71 kDa protein shows late clinical disease relevance led by systemic lupus erythematosus. 1 linked drug remains visible in the same block.
Start review with systemic lupus erythematosus because it currently carries late clinical support. Linked drugs include FORIGERIMOD ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHeat shock cognate 71 kDa protein
Review this target as Heat shock cognate 71 kDa protein, mapped to UniProt P11142. Sequence length is 646 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heat shock cognate 71 kDa protein as ChEMBL target CHEMBL1275223, mapped to UniProt P11142. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Heat shock cognate 71 kDa protein is the right protein anchor across sources, using UniProt P11142 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why systemic lupus erythematosus is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Heat shock cognate 71 kDa protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11142 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Heat shock cognate 71 kDa protein |
| UniProt Accession | P11142 |
| Component Type | Protein |
| Sequence Length | 646 aa |
Heat shock cognate 71 kDa protein
Review this target as Heat shock cognate 71 kDa protein, mapped to UniProt P11142. Sequence length is 646 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Heat shock cognate 71 kDa protein shows late clinical disease relevance led by systemic lupus erythematosus.
Start review with systemic lupus erythematosus because it currently carries late clinical support. Linked drugs include FORIGERIMOD ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1232461 | 7.25 | Kd | 56.0 | Clinical |
| CHEMBL3752910 | 6.95 | Kd | 111.14 | Preclinical |
| CHEMBL1232461 | 6.89 | IC50 | 130.0 | Clinical |
| CHEMBL14830 | 6.58 | Kd | 260.0 | Preclinical |
| CHEMBL14830 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL3427682 | 6.55 | Kd | 280.0 | Preclinical |
| CHEMBL3427679 | 6.53 | Kd | 295.12 | Preclinical |
| CHEMBL3091929 | 6.4 | Kd | 400.0 | Preclinical |
| CHEMBL3822603 | 6.34 | Kd | 457.09 | Preclinical |
| CHEMBL5639838 | 6.2 | Kd | 625.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 28 | 91 | 5.4 |
| cell-based format | 15 | 2 | 5.6 |
| subcellular format | 1 | 0 | — |