Cytochrome b-245 heavy chain · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P04839. Use UniProt P04839 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04839 as the stable identity anchor, then attach disease evidence before program review.
NADPH oxidase 2
Review this target as Cytochrome b-245 heavy chain, mapped to UniProt P04839. ChEMBL maps the protein component as NADPH oxidase 2. Sequence length is 570 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome b-245 heavy chain as ChEMBL target CHEMBL1287627, mapped to UniProt P04839. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome b-245 heavy chain |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P04839 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NADPH oxidase 2 |
| UniProt Accession | P04839 |
| Component Type | Protein |
| Sequence Length | 570 aa |
NADPH oxidase 2
Review this target as Cytochrome b-245 heavy chain, mapped to UniProt P04839. ChEMBL maps the protein component as NADPH oxidase 2. Sequence length is 570 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3347550 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3347551 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3733336 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL5413611 | 7.27 | Ki | 54.0 | Preclinical |
| CHEMBL397686 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL4210329 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL5413611 | 6.83 | IC50 | 149.0 | Preclinical |
| CHEMBL51085 | 6.52 | IC50 | 300.0 | Clinical |
| CHEMBL1927146 | 6.44 | Ki | 365.0 | Preclinical |
| CHEMBL1927160 | 6.36 | Ki | 433.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 34 | 38 | 5.0 |
| single protein format | 12 | 34 | 5.8 |
| assay format | 1 | 5 | 4.9 |
| cell-free format | 1 | 39 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 17 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 2 | 5.2 |