RecQ-like DNA helicase BLM · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P54132. Use UniProt P54132 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54132 as the stable identity anchor, then attach disease evidence before program review.
RecQ-like DNA helicase BLM
Review this target as RecQ-like DNA helicase BLM, mapped to UniProt P54132. Sequence length is 1417 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats RecQ-like DNA helicase BLM as ChEMBL target CHEMBL1293237, mapped to UniProt P54132. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether RecQ-like DNA helicase BLM is the right protein anchor across sources, using UniProt P54132 as the stable mapping.
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| Preferred Name | RecQ-like DNA helicase BLM |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P54132 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RecQ-like DNA helicase BLM |
| UniProt Accession | P54132 |
| Component Type | Protein |
| Sequence Length | 1417 aa |
RecQ-like DNA helicase BLM
Review this target as RecQ-like DNA helicase BLM, mapped to UniProt P54132. Sequence length is 1417 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2426190 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL2426164 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL2426169 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL4633662 | 6.12 | Kd | 760.0 | Preclinical |
| CHEMBL4633662 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL5423610 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL2426165 | 6.04 | IC50 | 910.0 | Preclinical |
| CHEMBL4075790 | 6.02 | IC50 | 950.0 | Preclinical |
| CHEMBL2426174 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL2426193 | 5.89 | IC50 | 1300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 45 | 21 | 5.5 |
| single protein format | 16 | 42 | 5.2 |
| assay format | 14 | 22 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |