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Target Snapshot

CHEMBL1293239 Target Snapshot

Bcl-2-related protein A1 · SINGLE PROTEIN · Mus musculus

499Compounds
5Assays
1Approved Drugs
694.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q07440. Use UniProt Q07440 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q07440 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bcl-2-related protein A1 as ChEMBL target CHEMBL1293239, mapped to UniProt Q07440. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bcl-2-related protein A1
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL1293239
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q07440
Bcl-2-related protein A1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bcl-2-related protein A1 is the right protein anchor across sources, using UniProt Q07440 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBcl-2-related protein A1
UniProt AccessionQ07440
Component TypeProtein
Sequence Length172 aa

Bcl-2-related protein A1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Bcl-2-related protein A1, mapped to UniProt Q07440. Sequence length is 172 aa.

Mapped IDQ07440
Review nameBcl-2-related protein A1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50694.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1271764 6.44 IC50 362.0 Preclinical
CHEMBL1384172 6.44 IC50 360.0 Preclinical
CHEMBL1269202 6.38 IC50 419.0 Preclinical
CHEMBL1272154 6.38 IC50 420.0 Preclinical
CHEMBL1531647 6.3 IC50 500.0 Preclinical
CHEMBL1310325 6.26 IC50 550.0 Preclinical
CHEMBL1272100 6.25 IC50 556.0 Preclinical
CHEMBL1323507 6.25 IC50 565.0 Preclinical
CHEMBL1271495 6.23 IC50 594.0 Preclinical
CHEMBL1519581 6.13 IC50 740.0 Preclinical
Distribution

pChEMBL Value Distribution

78
5.0
55
5.5
22
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
89
Tested Compounds
2
Assay Types
Binding — 4 assays, 89 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 89 5.4
Functional — 1 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 47 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine