Nucleotide-binding oligomerization domain-containing protein 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Nucleotide-binding oligomerization domain-containing protein 2 shows approved-linked disease relevance led by bone osteosarcoma. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9HC29. Start with bone osteosarcoma, then reuse UniProt Q9HC29 as the stable protein anchor across project notes and exports.
Start with bone osteosarcoma, then reuse UniProt Q9HC29 as the stable protein anchor across project notes and exports.
Nucleotide-binding oligomerization domain-containing protein 2 shows approved-linked disease relevance led by bone osteosarcoma. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with bone osteosarcoma because it currently carries approved-linked support. Linked drugs include MIFAMURTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNucleotide-binding oligomerization domain-containing protein 2
Review this target as Nucleotide-binding oligomerization domain-containing protein 2, mapped to UniProt Q9HC29. Sequence length is 1040 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nucleotide-binding oligomerization domain-containing protein 2 as ChEMBL target CHEMBL1293266, mapped to UniProt Q9HC29. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Nucleotide-binding oligomerization domain-containing protein 2 is the right protein anchor across sources, using UniProt Q9HC29 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why bone osteosarcoma is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Nucleotide-binding oligomerization domain-containing protein 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9HC29 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nucleotide-binding oligomerization domain-containing protein 2 |
| UniProt Accession | Q9HC29 |
| Component Type | Protein |
| Sequence Length | 1040 aa |
Nucleotide-binding oligomerization domain-containing protein 2
Review this target as Nucleotide-binding oligomerization domain-containing protein 2, mapped to UniProt Q9HC29. Sequence length is 1040 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Nucleotide-binding oligomerization domain-containing protein 2 shows approved-linked disease relevance led by bone osteosarcoma. 2 more disease programs remain visible in the same review block.
Start review with bone osteosarcoma because it currently carries approved-linked support. Linked drugs include MIFAMURTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4781373 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4847211 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4514780 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4853179 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5180843 | 8.35 | EC50 | 4.5 | Preclinical |
| CHEMBL4864576 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL4870434 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL4858463 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL1595790 | 8.0 | EC50 | 10.0 | Preclinical |
| CHEMBL4859716 | 7.89 | IC50 | 13.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 92 | 230 | 6.0 |
| single protein format | 14 | 5 | 6.5 |
| assay format | 6 | 1 | 6.7 |
| tissue-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 232 | 5.2 |
| cell-based format | 1 | 0 | — |