NS3 · SINGLE PROTEIN · Hepatitis C virus
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As of 2026-09-13Protein identity stays anchored to UniProt A3EZJ3. Use UniProt A3EZJ3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt A3EZJ3 as the stable identity anchor, then attach disease evidence before program review.
Genome polyprotein
Review this target as NS3, mapped to UniProt A3EZJ3. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 631 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NS3 as ChEMBL target CHEMBL1293269, mapped to UniProt A3EZJ3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NS3 |
| Target Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus |
| UniProt | A3EZJ3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Genome polyprotein |
| UniProt Accession | A3EZJ3 |
| Component Type | Protein |
| Sequence Length | 631 aa |
Genome polyprotein
Review this target as NS3, mapped to UniProt A3EZJ3. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 631 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2063090 | 10.4 | Ki | 0.04 | Approved |
| CHEMBL505440 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL3899923 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL297884 | 10.05 | Ki | 0.089 | Clinical |
| CHEMBL3661086 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL489267 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL444708 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL4215698 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL3661088 | 9.6 | Ki | 0.25 | Preclinical |
| CHEMBL4202696 | 9.52 | EC50 | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 105 | 777 | 6.3 |
| cell-based format | 5 | 22 | 8.0 |