Eyes absent homolog 2 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt O00167. Use UniProt O00167 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O00167 as the stable identity anchor, then attach disease evidence before program review.
Protein phosphatase EYA2
Review this target as Eyes absent homolog 2, mapped to UniProt O00167. ChEMBL maps the protein component as Protein phosphatase EYA2. Sequence length is 538 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Eyes absent homolog 2 as ChEMBL target CHEMBL1293275, mapped to UniProt O00167. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Eyes absent homolog 2 is the right protein anchor across sources, using UniProt O00167 as the stable mapping.
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| Preferred Name | Eyes absent homolog 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00167 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein phosphatase EYA2 |
| UniProt Accession | O00167 |
| Component Type | Protein |
| Sequence Length | 538 aa |
Protein phosphatase EYA2
Review this target as Eyes absent homolog 2, mapped to UniProt O00167. ChEMBL maps the protein component as Protein phosphatase EYA2. Sequence length is 538 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4463681 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL3191598 | 5.64 | IC50 | 2300.0 | Preclinical |
| CHEMBL4459891 | 5.46 | IC50 | 3450.0 | Preclinical |
| CHEMBL4530754 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL1975051 | 5.14 | IC50 | 7300.0 | Preclinical |
| CHEMBL388590 | 4.99 | IC50 | 10300.0 | Approved |
| CHEMBL3189517 | 4.78 | IC50 | 16800.0 | Preclinical |
| CHEMBL3190554 | 4.78 | IC50 | 16800.0 | Preclinical |
| CHEMBL3195222 | 4.78 | IC50 | 16800.0 | Preclinical |
| CHEMBL4445513 | 4.78 | IC50 | 16800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 21 | 17 | 4.8 |
| cell-based format | 8 | 0 | — |
| single protein format | 4 | 1 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |