NPC intracellular cholesterol transporter 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O15118. Use UniProt O15118 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15118 as the stable identity anchor, then attach disease evidence before program review.
NPC intracellular cholesterol transporter 1
Review this target as NPC intracellular cholesterol transporter 1, mapped to UniProt O15118. Sequence length is 1278 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NPC intracellular cholesterol transporter 1 as ChEMBL target CHEMBL1293277, mapped to UniProt O15118. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether NPC intracellular cholesterol transporter 1 is the right protein anchor across sources, using UniProt O15118 as the stable mapping.
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| Preferred Name | NPC intracellular cholesterol transporter 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15118 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NPC intracellular cholesterol transporter 1 |
| UniProt Accession | O15118 |
| Component Type | Protein |
| Sequence Length | 1278 aa |
NPC intracellular cholesterol transporter 1
Review this target as NPC intracellular cholesterol transporter 1, mapped to UniProt O15118. Sequence length is 1278 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3311372 | 6.82 | EC50 | 150.0 | Preclinical |
| CHEMBL2418982 | 5.8 | EC50 | 1600.0 | Preclinical |
| CHEMBL4092121 | 5.44 | EC50 | 3600.0 | Preclinical |
| CHEMBL4076151 | 5.38 | EC50 | 4200.0 | Preclinical |
| CHEMBL3297906 | 4.96 | EC50 | 11000.0 | Preclinical |
| CHEMBL3298091 | 4.89 | EC50 | 13000.0 | Preclinical |
| CHEMBL4075007 | 4.85 | EC50 | 14000.0 | Preclinical |
| CHEMBL4085267 | 4.85 | EC50 | 14000.0 | Preclinical |
| CHEMBL4097145 | 4.8 | EC50 | 16000.0 | Preclinical |
| CHEMBL4070989 | 4.72 | EC50 | 19000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 10 | 5.1 |
| single protein format | 2 | 1 | 5.8 |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |