Use UniProt Q9Y6Q9 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL1615382 Target Snapshot
Nuclear receptor coactivator 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y6Q9. Use UniProt Q9Y6Q9 as the stable identity anchor, then attach disease evidence before program review.
Nuclear receptor coactivator 3
Review this target as Nuclear receptor coactivator 3, mapped to UniProt Q9Y6Q9. Sequence length is 1424 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Nuclear receptor coactivator 3 as ChEMBL target CHEMBL1615382, mapped to UniProt Q9Y6Q9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nuclear receptor coactivator 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y6Q9 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nuclear receptor coactivator 3 |
| UniProt Accession | Q9Y6Q9 |
| Component Type | Protein |
| Sequence Length | 1424 aa |
Nuclear receptor coactivator 3
How to read this target
Review this target as Nuclear receptor coactivator 3, mapped to UniProt Q9Y6Q9. Sequence length is 1424 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL132431 | 7.73 | IC50 | 18.61 | Preclinical |
| CHEMBL1571037 | 7.04 | IC50 | 91.26 | Preclinical |
| CHEMBL34259 | 6.68 | IC50 | 210.97 | Approved |
| CHEMBL44657 | 6.43 | IC50 | 374.72 | Approved |
| CHEMBL1699187 | 6.36 | IC50 | 434.07 | Preclinical |
| CHEMBL1373969 | 6.3 | IC50 | 503.09 | Preclinical |
| CHEMBL1705854 | 6.28 | IC50 | 521.85 | Preclinical |
| CHEMBL1713127 | 6.18 | IC50 | 660.61 | Preclinical |
| CHEMBL1611106 | 6.16 | IC50 | 694.34 | Preclinical |
| CHEMBL1306377 | 6.12 | IC50 | 762.3 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 2 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
Functional — 1 assays, 209 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 209 | 5.3 |