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Target Snapshot

CHEMBL1626502 Target Snapshot

PPC-1 · CELL-LINE · Homo sapiens

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286Compounds
19Assays
4Approved Drugs
286.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PPC-1 as ChEMBL target CHEMBL1626502. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PPC-1
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1626502
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PPC-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePPC-1
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPPC-1
UniProt AccessionN/A

PPC-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PPC-1.

Review namePPC-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC50285.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428647 8.47 IC50 3.4 Approved
CHEMBL499424 8.22 IC50 6.0 Preclinical
CHEMBL1830231 8.1 IC50 8.0 Preclinical
CHEMBL2322317 8.1 IC50 8.0 Preclinical
CHEMBL513054 8.1 IC50 8.0 Preclinical
CHEMBL2322314 8.0 IC50 10.0 Preclinical
CHEMBL34259 8.0 IC50 10.0 Approved
CHEMBL1272023 7.96 IC50 11.0 Preclinical
CHEMBL2322311 7.89 IC50 13.0 Preclinical
CHEMBL2323920 7.89 IC50 13.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
36
5.5
37
6.0
19
6.5
34
7.0
28
7.5
7
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

19
Total Assays
184
Tested Compounds
1
Assay Types
Functional — 19 assays, 184 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 184 6.5
organism-based format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine