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Evidence Snapshot

Apelin receptor

CHEMBL1628481 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:31:06Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1628481
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Apelin receptor as ChEMBL target CHEMBL1628481, mapped to UniProt P35414. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Apelin receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1628481
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35414
Apelin receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Apelin receptor matters

As of 2026-09-13

Apelin receptor is reviewed as Apelin receptor (UniProt P35414); Apelin receptor shows clinical signal disease relevance led by diabetes mellitus.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 5 approved drugs, 3953 compounds, and 139 assays, with lead potency reaching pChEMBL 11.0.

Disease context
diabetes mellitus

Apelin receptor shows clinical signal disease relevance led by diabetes mellitus. 1 linked drug keep the rationale reviewable. Linked drugs include APELIN.

Start review with diabetes mellitus because it currently carries clinical signal support. Linked drugs include APELIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Clinical signal 1 linked drug
Activity base
Portfolio and assay base

ChEMBL currently tracks 5 approved drugs, 3953 compounds, and 139 assays for this target. The dominant activity type is EC50. CHEMBL4851100 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL4851100 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
5 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Apelin receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P35414, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why diabetes mellitus is currently treated as clinical signal support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

3953
Total Compounds
139
Total Assays
5
Approved Drugs
IC50: 160.0, KI: 289.0, EC50: 5979.0, KD: 1.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4851100
 11.0 EC50 —
No preferred name
CHEMBL4878056
 11.0 EC50 —
No preferred name
CHEMBL3184840
 10.9 EC50 —
No preferred name
CHEMBL3417384
 10.8 Ki —
No preferred name
CHEMBL4864542
 10.7 EC50 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:31:06Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1628481