DNA-directed RNA polymerase II subunit RPB1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14DNA-directed RNA polymerase II subunit RPB1 shows clinical signal disease relevance led by head and neck malignant neoplasia. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P24928. Start with head and neck malignant neoplasia, then reuse UniProt P24928 as the stable protein anchor across project notes and exports.
Start with head and neck malignant neoplasia, then reuse UniProt P24928 as the stable protein anchor across project notes and exports.
DNA-directed RNA polymerase II subunit RPB1 shows clinical signal disease relevance led by head and neck malignant neoplasia. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with head and neck malignant neoplasia because it currently carries clinical signal support. Linked drugs include TAS-106. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDNA-directed RNA polymerase II subunit RPB1
Review this target as DNA-directed RNA polymerase II subunit RPB1, mapped to UniProt P24928. Sequence length is 1970 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA-directed RNA polymerase II subunit RPB1 as ChEMBL target CHEMBL1641353, mapped to UniProt P24928. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether DNA-directed RNA polymerase II subunit RPB1 is the right protein anchor across sources, using UniProt P24928 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why head and neck malignant neoplasia is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | DNA-directed RNA polymerase II subunit RPB1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P24928 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA-directed RNA polymerase II subunit RPB1 |
| UniProt Accession | P24928 |
| Component Type | Protein |
| Sequence Length | 1970 aa |
DNA-directed RNA polymerase II subunit RPB1
Review this target as DNA-directed RNA polymerase II subunit RPB1, mapped to UniProt P24928. Sequence length is 1970 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
DNA-directed RNA polymerase II subunit RPB1 shows clinical signal disease relevance led by head and neck malignant neoplasia. 1 more disease program remain visible in the same review block.
Start review with head and neck malignant neoplasia because it currently carries clinical signal support. Linked drugs include TAS-106. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1232461 | 6.82 | IC50 | 150.0 | Clinical |
| CHEMBL1232461 | 6.8 | Kd | 157.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 2 | 6.8 |