C-C motif chemokine 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14C-C motif chemokine 2 shows clinical signal disease relevance led by prostate cancer. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P13500. Start with prostate cancer, then reuse UniProt P13500 as the stable protein anchor across project notes and exports.
Start with prostate cancer, then reuse UniProt P13500 as the stable protein anchor across project notes and exports.
C-C motif chemokine 2 shows clinical signal disease relevance led by prostate cancer. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with prostate cancer because it currently carries clinical signal support. Linked drugs include CARLUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyC-C motif chemokine 2
Review this target as C-C motif chemokine 2, mapped to UniProt P13500. Sequence length is 99 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats C-C motif chemokine 2 as ChEMBL target CHEMBL1649052, mapped to UniProt P13500. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether C-C motif chemokine 2 is the right protein anchor across sources, using UniProt P13500 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why prostate cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | C-C motif chemokine 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P13500 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | C-C motif chemokine 2 |
| UniProt Accession | P13500 |
| Component Type | Protein |
| Sequence Length | 99 aa |
C-C motif chemokine 2
Review this target as C-C motif chemokine 2, mapped to UniProt P13500. Sequence length is 99 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
C-C motif chemokine 2 shows clinical signal disease relevance led by prostate cancer. 2 more disease programs remain visible in the same review block.
Start review with prostate cancer because it currently carries clinical signal support. Linked drugs include CARLUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5426022 | 10.4 | IC50 | 0.03981 | Preclinical |
| CHEMBL5422047 | 9.6 | IC50 | 0.2512 | Preclinical |
| CHEMBL4078100 | 8.5 | IC50 | 3.162 | Preclinical |
| CHEMBL1957266 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL5433432 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL4438171 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL5403564 | 7.9 | IC50 | 12.59 | Preclinical |
| CHEMBL5220494 | 7.8 | IC50 | 15.85 | Preclinical |
| CHEMBL4648362 | 7.7 | IC50 | 19.95 | Preclinical |
| CHEMBL5219991 | 7.7 | IC50 | 19.95 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 7 | 6.5 |
| cell-based format | 8 | 13 | 7.5 |
| tissue-based format | 7 | 51 | 6.7 |