Use UniProt Q1A7N1 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL1667665 Target Snapshot
Transient receptor potential M8 protein · SINGLE PROTEIN · Canis familiaris
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As of 2026-09-14Protein identity stays anchored to UniProt Q1A7N1. Use UniProt Q1A7N1 as the stable identity anchor, then attach disease evidence before program review.
Transient receptor potential M8 protein
Review this target as Transient receptor potential M8 protein, mapped to UniProt Q1A7N1. Sequence length is 1104 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Transient receptor potential M8 protein as ChEMBL target CHEMBL1667665, mapped to UniProt Q1A7N1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Transient receptor potential M8 protein |
| Target Type | SINGLE PROTEIN |
| Organism | Canis familiaris |
| UniProt | Q1A7N1 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transient receptor potential M8 protein |
| UniProt Accession | Q1A7N1 |
| Component Type | Protein |
| Sequence Length | 1104 aa |
Transient receptor potential M8 protein
How to read this target
Review this target as Transient receptor potential M8 protein, mapped to UniProt Q1A7N1. Sequence length is 1104 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3974529 | 9.74 | IC50 | 0.183 | Preclinical |
| CHEMBL1650528 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3353610 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3944014 | 9.28 | IC50 | 0.53 | Preclinical |
| CHEMBL3984325 | 9.23 | IC50 | 0.59 | Preclinical |
| CHEMBL1650519 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3900167 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3968936 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3937976 | 9.16 | IC50 | 0.69 | Preclinical |
| CHEMBL1650523 | 9.15 | IC50 | 0.7 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 6 assays, 948 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 948 | 7.8 |
Functional — 6 assays, 75 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 75 | 7.6 |