Signal transducer and activator of transcription 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P42225. Use UniProt P42225 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42225 as the stable identity anchor, then attach disease evidence before program review.
Signal transducer and activator of transcription 1
Review this target as Signal transducer and activator of transcription 1, mapped to UniProt P42225. Sequence length is 749 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Signal transducer and activator of transcription 1 as ChEMBL target CHEMBL1667670, mapped to UniProt P42225. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Signal transducer and activator of transcription 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P42225 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Signal transducer and activator of transcription 1 |
| UniProt Accession | P42225 |
| Component Type | Protein |
| Sequence Length | 749 aa |
Signal transducer and activator of transcription 1
Review this target as Signal transducer and activator of transcription 1, mapped to UniProt P42225. Sequence length is 749 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1684872 | 5.2 | Ki | 6300.0 | Preclinical |
| CHEMBL4746031 | 4.92 | IC50 | 12000.0 | Preclinical |
| CHEMBL1681824 | 4.78 | Ki | 16500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 0 | — |
| single protein format | 5 | 0 | — |
| assay format | 1 | 2 | 5.0 |
| subcellular format | 1 | 1 | 4.9 |
| tissue-based format | 1 | 0 | — |