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Target Snapshot

CHEMBL1667695 Target Snapshot

Metallo-beta-lactamase type 2 · SINGLE PROTEIN · Klebsiella pneumoniae

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125Compounds
70Assays
3Approved Drugs
55.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt C7C422. Use UniProt C7C422 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt C7C422 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Metallo-beta-lactamase type 2 as ChEMBL target CHEMBL1667695, mapped to UniProt C7C422. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Metallo-beta-lactamase type 2
SINGLE PROTEIN · Klebsiella pneumoniae
As of 2026-09-14
ChEMBL target ID
CHEMBL1667695
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
C7C422
Metallo-beta-lactamase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Metallo-beta-lactamase type 2 is the right protein anchor across sources, using UniProt C7C422 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMetallo-beta-lactamase type 2
Target TypeSINGLE PROTEIN
OrganismKlebsiella pneumoniae
UniProtC7C422
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMetallo-beta-lactamase type 2
UniProt AccessionC7C422
Component TypeProtein
Sequence Length270 aa

Metallo-beta-lactamase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Metallo-beta-lactamase type 2, mapped to UniProt C7C422. Sequence length is 270 aa.

Mapped IDC7C422
Review nameMetallo-beta-lactamase type 2
OrganismKlebsiella pneumoniae
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5037.0
KI7.0
KD11.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3810052 6.82 IC50 150.0 Preclinical
CHEMBL3808671 6.8 IC50 160.0 Preclinical
CHEMBL3809576 6.8 IC50 160.0 Preclinical
CHEMBL3809719 6.8 IC50 160.0 Preclinical
CHEMBL3809806 6.8 IC50 160.0 Preclinical
CHEMBL3809713 6.77 IC50 170.0 Preclinical
CHEMBL3808678 6.72 IC50 190.0 Preclinical
CHEMBL3809860 6.64 IC50 230.0 Preclinical
CHEMBL3808891 6.48 IC50 330.0 Preclinical
CHEMBL3809469 6.46 IC50 350.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
3
5.5
16
6.0
8
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

70
Total Assays
34
Tested Compounds
1
Assay Types
Binding — 70 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 44 2 5.1
assay format 19 2 5.0
cell-based format 7 30 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine