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Target Snapshot

CHEMBL1681616 Target Snapshot

Accessory gene regulator protein A · SINGLE PROTEIN · Staphylococcus aureus

19Compounds
9Assays
0Approved Drugs
15.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A0I7. Use UniProt P0A0I7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A0I7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Accessory gene regulator protein A as ChEMBL target CHEMBL1681616, mapped to UniProt P0A0I7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Accessory gene regulator protein A
SINGLE PROTEIN · Staphylococcus aureus
As of 2026-09-14
ChEMBL target ID
CHEMBL1681616
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A0I7
Accessory gene regulator protein A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Accessory gene regulator protein A is the right protein anchor across sources, using UniProt P0A0I7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAccessory gene regulator protein A
UniProt AccessionP0A0I7
Component TypeProtein
Sequence Length238 aa

Accessory gene regulator protein A

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Accessory gene regulator protein A, mapped to UniProt P0A0I7. Sequence length is 238 aa.

Mapped IDP0A0I7
Review nameAccessory gene regulator protein A
OrganismStaphylococcus aureus
Assay Mix

Activity Type Distribution

IC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3289785 7.92 IC50 12.0 Preclinical
CHEMBL3742171 6.52 IC50 300.0 Preclinical
CHEMBL1784527 6.1 IC50 800.0 Preclinical
CHEMBL3740058 5.6 IC50 2500.0 Preclinical
CHEMBL3741390 5.36 IC50 4400.0 Preclinical
CHEMBL8483 5.22 IC50 6000.0 Preclinical
CHEMBL290932 5.09 IC50 8100.0 Preclinical
CHEMBL3289786 5.05 IC50 8900.0 Preclinical
CHEMBL289277 4.77 IC50 17100.0 Preclinical
CHEMBL3289787 4.7 IC50 19800.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
1
5.5
1
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
15
Tested Compounds
1
Assay Types
Binding — 9 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 15 5.3
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine