Dihydrofolate reductase · SINGLE PROTEIN · Staphylococcus aureus
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As of 2026-09-13Protein identity stays anchored to UniProt P0A017. Use UniProt P0A017 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0A017 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P0A017. Sequence length is 159 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL1681620, mapped to UniProt P0A017. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
| UniProt | P0A017 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P0A017 |
| Component Type | Protein |
| Sequence Length | 159 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P0A017. Sequence length is 159 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3128015 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL3681407 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL3128018 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL3128014 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL3128026 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL3681408 | 10.72 | Ki | 0.019 | Preclinical |
| CHEMBL3128017 | 10.72 | Ki | 0.019 | Preclinical |
| CHEMBL1818127 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL3681412 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL3127912 | 10.66 | Ki | 0.022 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 31 | 152 | 8.4 |
| assay format | 9 | 48 | 7.3 |
| cell-based format | 6 | 18 | 7.3 |