Cyclic nucleotide specific phosphodiesterase · SINGLE PROTEIN · Trypanosoma cruzi
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As of 2026-09-14Protein identity stays anchored to UniProt Q53I59. Use UniProt Q53I59 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q53I59 as the stable identity anchor, then attach disease evidence before program review.
Phosphodiesterase
Review this target as Cyclic nucleotide specific phosphodiesterase, mapped to UniProt Q53I59. ChEMBL maps the protein component as Phosphodiesterase. Sequence length is 924 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclic nucleotide specific phosphodiesterase as ChEMBL target CHEMBL1681621, mapped to UniProt Q53I59. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cyclic nucleotide specific phosphodiesterase is the right protein anchor across sources, using UniProt Q53I59 as the stable mapping.
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| Preferred Name | Cyclic nucleotide specific phosphodiesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi |
| UniProt | Q53I59 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphodiesterase |
| UniProt Accession | Q53I59 |
| Component Type | Protein |
| Sequence Length | 924 aa |
Phosphodiesterase
Review this target as Cyclic nucleotide specific phosphodiesterase, mapped to UniProt Q53I59. ChEMBL maps the protein component as Phosphodiesterase. Sequence length is 924 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL456617 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL1673333 | 5.62 | IC50 | 2400.0 | Preclinical |
| CHEMBL456826 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL457663 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL458932 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL455962 | 5.51 | IC50 | 3100.0 | Preclinical |
| CHEMBL458933 | 5.5 | IC50 | 3200.0 | Preclinical |
| CHEMBL511686 | 5.5 | IC50 | 3200.0 | Preclinical |
| CHEMBL1673316 | 5.48 | IC50 | 3300.0 | Preclinical |
| CHEMBL447757 | 5.46 | IC50 | 3500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 31 | 5.4 |